NOX4 and its association with myeloperoxidase and osteopontin in regulating endochondral ossification.

Kayoung Ko Seohee Choi Miri Jo Chaeyoung Kim Napissara Boonpraman Jihyun Youm Sun Shin Yi

Published in: Journal of veterinary science (2024)

Our results emphasize NOX4's significance in bone morphology, mesenchymal stem cell proteomics, immunohistochemistry, collagen levels, and chondrogenesis. NOX4 deficiency enhances bone development and endochondral ossification, potentially through increased MPO, OPN, and COLII expression. These findings suggest therapeutic implications for skeletal disorders.

Keyphrases

reactive oxygen species
bone mineral density
mesenchymal stem cells
poor prognosis
soft tissue
mass spectrometry
bone regeneration
bone marrow
postmenopausal women
stem cells
wound healing
replacement therapy
cell therapy