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A porcine xenograft-derived bone scaffold is a biocompatible bone graft substitute: An assessment of cytocompatibility and the alpha-Gal epitope.

Daniel N BraceyThorsten M SeylerAlexander H JinnahThomas L SmithDavid A OrnellesRajendar DeoraGriffith D ParksMark E Van DykePatrick W Whitlock
Published in: Xenotransplantation (2019)
The current investigation supports the biologic safety of bone scaffolds derived from porcine donors using a decellularization protocol that meets current sterility assurance standards. The majority of the highly immunogenic xenograft carbohydrate was removed from donor tissue, and these findings support further in vivo investigation of xenograft-derived bone tissue for orthopedic clinical application.
Keyphrases
  • bone mineral density
  • bone loss
  • bone regeneration
  • randomized controlled trial
  • postmenopausal women
  • tissue engineering
  • body composition
  • drug delivery
  • quality control