Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells.

Li-Dong LiuYing-Xin PangXin-Rui ZhaoRui LiCheng-Juan JinJing XueRui-Ying DongPei-Shu Liu

Published in: Archives of gynecology and obstetrics (2019)

Curcumin can induce protective autophagy of human ovarian cancer cells by inhibiting the AKT/mTOR/p70S6K pathway, indicating the synergistic effects of curcumin and autophagy inhibition as a possible strategy to overcome the limits of current therapies in the eradication of epithelial ovarian cancer.

Keyphrases

cell death
signaling pathway
endothelial cells
cell proliferation
cell cycle arrest
endoplasmic reticulum stress
induced pluripotent stem cells
pi k akt
oxidative stress
pluripotent stem cells
drug delivery
helicobacter pylori infection