Correlated downregulation of VDR and CYP3A4 in colorectal cancer.

Hossein SadeghiVeys HashemniaEhsan Nazemalhosseini-MojaradMohammad Reza GhasemiReza Mirfakhraie

Published in: Molecular biology reports (2022)

Reduction in the expression of both CYP3A4 and VDR plays an important role in CRC due to the possible impairment in vitamin D metabolism. Further studies concerning the relationship between the expression of these genes and colorectal cancer pathogenesis and treatment are recommended.

Keyphrases

poor prognosis
binding protein
cell proliferation
long non coding rna
signaling pathway
genome wide
genome wide identification