Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas.

Ying TianEri AraiSatomi MakiuchiNoboru TsudaJunko KuramotoKentaro OharaYoriko TakahashiNanako ItoHidenori OjimaNobuyoshi HiraokaMasahiro GotohTeruhiko YoshidaYae Kanai

Published in: Journal of cancer research and clinical oncology (2020)

DNA methylation alterations may occur under the necroinflammatory conditions characteristic of NASH and participate in NASH-related hepatocarcinogenesis through aberrant expression of tumor-related genes.

Keyphrases

dna methylation
gene expression
genome wide
poor prognosis
copy number
binding protein
drug induced