Multicenter Surveillance of Antimicrobial Resistance among Gram-Negative Bacteria Isolated from Bloodstream Infections in Ghana.
Eric S DonkorKhitam MuhsenSherry A M JohnsonFleischer C N KoteyNicholas T K D DayiePatience B Tetteh-QuarcooEdem M A TetteMary-Magdalene OseiBeverly EgyirNicholas Israel Nii-TrebiGodfred Owusu-OkyereAlex Kwame Owusu-OforiYonatan AmirSaritte PerlmanPerdita Hilary LopesAdjo MfodwoNicola C GordonLouise GreshamMark SmolinskiDani CohenPublished in: Antibiotics (Basel, Switzerland) (2023)
Multicenter AMR surveillance of Gram-negative blood isolates from febrile patients was well-received in Ghana, and the implementation of a harmonized protocol was feasible. High resistance and multidrug resistance to first- or second-choice antibiotics, including penicillins, third-generation cephalosporins, and fluoroquinolones, were found, implying that these antibiotics might have limited effectiveness in BSI treatment in the country. Continuation of AMR surveillance in Gram-negative blood isolates is essential for a better understanding of the extent of AMR in these pathogens and to guide clinical practice and policymaking.
Keyphrases
- gram negative
- antimicrobial resistance
- multidrug resistant
- public health
- end stage renal disease
- randomized controlled trial
- clinical practice
- ejection fraction
- newly diagnosed
- chronic kidney disease
- primary care
- healthcare
- systematic review
- prognostic factors
- peritoneal dialysis
- patient reported outcomes
- quality improvement
- combination therapy
- replacement therapy