Investigation of the Active Ingredients and Mechanism of Polygonum cuspidatum in Asthma Based on Network Pharmacology and Experimental Verification.

Junjie BiYuhua LinYipeng SunMengzhe ZhangQingge ChenXiayi MiuLingling TangJinjin LiuLinyun ZhuZhenhua NiXiongbiao Wang

Published in: Drug design, development and therapy (2021)

Polygonum cuspidatum could alleviate the symptoms of asthma including ASM cells proliferation and MUC5AC expression through the mechanisms predicted by network pharmacology, which provides a basis for further understanding of Polygonum cuspidatum in the treatment of asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
induced apoptosis
poor prognosis
signaling pathway
cell cycle arrest
cell death
physical activity
replacement therapy