CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [68Ga]Ga-Pentixafor /[177Lu]Lu-Pentixather.
Sarah M JacobsPieter WesselingBart de KeizerNelleke TolboomF F Tessa VerversGerard C KrijgerBart A WestermanTom J SnijdersPierre A RobeAnja Gwendolyn van der KolkPublished in: European journal of nuclear medicine and molecular imaging (2021)
Using immunohistochemistry, high CXCR4 expression was found in a subset of glioblastomas as well as a large inter- and intra-tumor variation. Caution should be exercised in directly translating ex vivo CXCR4 expression to PET agent uptake. However, when high CXCR4 expression can be identified with [68Ga]Ga-Pentixafor, these patients might be good candidates for targeted radionuclide therapy with [177Lu]Lu-Pentixather in the future.