SOMOphilic Alkynylation of Unreactive Alkenes Enabled by Iron-Catalyzed Hydrogen Atom Transfer.

Binlin ZhaoTianxiang ZhuMengtao MaZhuangzhi Shi

Published in: Molecules (Basel, Switzerland) (2021)

We report an efficient and practical iron-catalyzed hydrogen atom transfer protocol for assembling acetylenic motifs into functional alkenes. Diversities of internal alkynes could be obtained from readily available alkenes and acetylenic sulfones with excellent Markovnikov selectivity. An iron hydride hydrogen atom transfer catalytic cycle was described to clarify the mechanism of this reaction.

Keyphrases

electron transfer
molecular dynamics
iron deficiency
room temperature
randomized controlled trial
visible light