The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting.
Natsuki FurukawaVered StearnsCesar A Santa-MariaAleksander S PopelPublished in: Expert opinion on therapeutic targets (2023)
Single-cell omics studies have contributed to the classification of cells in the TME and the identification of important cell types involved in the progression and the treatment of the tumor. The interactions between cancer cells and stromal cells/immune cells in the TME have led to the discovery of potential therapeutic targets. Experimental data with spatial and temporal resolution will further boost the understanding of the TME of TNBC.
Keyphrases
- single cell
- rna seq
- high throughput
- induced apoptosis
- machine learning
- cell cycle arrest
- small molecule
- deep learning
- electronic health record
- stem cells
- cancer therapy
- single molecule
- drug delivery
- combination therapy
- risk assessment
- cell therapy
- cell death
- cell proliferation
- oxidative stress
- human health
- case control
- climate change
- pi k akt
- bone marrow