Aleksander S Popel

Loop profile Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 40

Top Venues

Expert opinion on therapeutic targets

Cancer research

NPJ digital medicine

PNAS nexus

Johns Hopkins University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Johns Hopkins University

United States

Professor :: Biomedical Engineering

Publications

Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S Popel
From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling. NPJ digital medicine 7 (1) (2024)
Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S Popel
From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling. NPJ digital medicine 7 (1) (2024)
Hanwen Wang, Theinmozhi Arulraj, Samira Anbari, Aleksander S Popel
Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC. Clinical and translational science 17 (6) (2024)
Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S Popel
From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling. NPJ digital medicine 7 (1) (2024)
Shuming Zhang, Atul Deshpande, Babita K Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth D Thompson, Qingfeng Zhu, Robert A Anders, Mark Yarchoan, Luciane Tsukamoto Kagohara, Elana J Fertig, Aleksander S Popel
Integration of Clinical Trial Spatial Multi-omics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery. Cancer research (2024)
Shuming Zhang, Atul Deshpande, Babita K Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth D Thompson, Qingfeng Zhu, Robert A Anders, Mark Yarchoan, Luciane Tsukamoto Kagohara, Elana J Fertig, Aleksander S Popel
Integration of Clinical Trial Spatial Multi-omics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery. Cancer research (2024)
Hanwen Wang, Theinmozhi Arulraj, Samira Anbari, Aleksander S Popel
Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC. Clinical and translational science 17 (6) (2024)
Shuming Zhang, Atul Deshpande, Babita K Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth D Thompson, Qingfeng Zhu, Robert A Anders, Mark Yarchoan, Luciane Tsukamoto Kagohara, Elana J Fertig, Aleksander S Popel
Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery. Cancer research 84 (16) (2024)
Hanwen Wang, Theinmozhi Arulraj, Samira Anbari, Aleksander S Popel
Quantitative systems pharmacology modeling of macrophage-targeted therapy combined with PD-L1 inhibition in advanced NSCLC. Clinical and translational science 17 (6) (2024)
Theinmozhi Arulraj, Hanwen Wang, Atul Deshpande, Ravi Varadhan, Leisha A Emens, Elizabeth D Thompson, Elana J Fertig, Cesar A Santa-Maria, Aleksander S Popel
Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade. bioRxiv : the preprint server for biology (2024)
Yu Zhang, Yuhao Qiang, He Li, Guansheng Li, Lu Lu, Ming Dao, George Em Karniadakis, Aleksander S Popel, Chen Zhao
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease. PNAS nexus 3 (2) (2024)
Yu Zhang, Yuhao Qiang, He Li, Guansheng Li, Lu Lu, Ming Dao, George Em Karniadakis, Aleksander S Popel, Chen Zhao
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease. PNAS nexus 3 (2) (2024)
Hanwen Wang, Theinmozhi Arulraj, Alberto Ippolito, Aleksander S Popel
From virtual patients to digital twins in immuno-oncology: lessons learned from mechanistic quantitative systems pharmacology modeling. NPJ digital medicine 7 (1) (2024)
Yu Zhang, Yuhao Qiang, He Li, Guansheng Li, Lu Lu, Ming Dao, George Em Karniadakis, Aleksander S Popel, Chen Zhao
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease. PNAS nexus 3 (2) (2024)
Shuming Zhang, Atul Deshpande, Babita K Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth D Thompson, Qingfeng Zhu, Robert A Anders, Mark Yarchoan, Luciane Tsukamoto Kagohara, Elana J Fertig, Aleksander S Popel
Integration of Clinical Trial Spatial Multiomics Analysis and Virtual Clinical Trials Enables Immunotherapy Response Prediction and Biomarker Discovery. Cancer research 84 (16) (2024)
Yu Zhang, Yuhao Qiang, He Li, Guansheng Li, Lu Lu, Ming Dao, George Em Karniadakis, Aleksander S Popel, Chen Zhao
Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease. PNAS nexus 3 (2) (2024)
Theinmozhi Arulraj, Hanwen Wang, Leisha A Emens, Cesar A Santa-Maria, Aleksander S Popel
A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition. Science advances 9 (26) (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Expert opinion on therapeutic targets (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Expert opinion on therapeutic targets 26 (12) (2023)
Min Song, Youli Wang, Brian H Annex, Aleksander S Popel
Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells. NPJ systems biology and applications 9 (1) (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Expert opinion on therapeutic targets 26 (12) (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Expert opinion on therapeutic targets 26 (12) (2023)
Alberto Ippolito, Hanwen Wang, Yu Zhang, Vahideh Vakil, Hojjat Bazzazi, Aleksander S Popel
Eliciting the antitumor immune response with a conditionally activated PD-L1 targeting antibody analyzed with a quantitative systems pharmacology model. CPT: pharmacometrics & systems pharmacology (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: Shedding light on mechanisms and targeting. Expert opinion on therapeutic targets (2023)
Theinmozhi Arulraj, Hanwen Wang, Leisha A Emens, Cesar A Santa-Maria, Aleksander S Popel
A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition. Science advances 9 (26) (2023)
Hanwen Wang, Theinmozhi Arulraj, Holly Kimko, Aleksander S Popel
Generating immunogenomic data-guided virtual patients using a QSP model to predict response of advanced NSCLC to PD-L1 inhibition. NPJ precision oncology 7 (1) (2023)
Mehdi Nikfar, Haoyang Mi, Chang Gong, Holly Kimko, Aleksander S Popel
Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model. Cancers 15 (10) (2023)
Rebeca Hannah M Oliveira, Brian H Annex, Aleksander S Popel
Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway. bioRxiv : the preprint server for biology (2023)
Rebeca Hannah M Oliveira, Brian H Annex, Aleksander S Popel
Endothelial cells signaling and patterning under hypoxia: a mechanistic integrative computational model including the Notch-Dll4 pathway. bioRxiv : the preprint server for biology (2023)
Theinmozhi Arulraj, Hanwen Wang, Leisha A Emens, Cesar A Santa-Maria, Aleksander S Popel
A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition. Science advances 9 (26) (2023)
Natsuki Furukawa, Vered Stearns, Cesar A Santa-Maria, Aleksander S Popel
The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting. Expert opinion on therapeutic targets 26 (12) (2023)
Hanwen Wang, Huilin Ma, Richard J Sové, Leisha A Emens, Aleksander S Popel
Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer. Journal for immunotherapy of cancer 9 (2) (2022)
Haoyang Mi, Shamilene Sivagnanam, Courtney B Betts, Shannon M Liudahl, Elizabeth D Thompson, Lisa M Coussens, Aleksander S Popel
Quantitative Spatial Profiling of Immune Populations in Pancreatic Ductal Adenocarcinoma Reveals Tumor Microenvironment Heterogeneity and Prognostic Biomarkers. Cancer research 82 (23) (2022)
Yu Zhang, Christopher D Kontos, Brian H Annex, Aleksander S Popel
A systems biology model of junctional localization and downstream signaling of the Ang-Tie signaling pathway. NPJ systems biology and applications 7 (1) (2021)
Chang Gong, Alvaro Ruiz-Martinez, Holly Kimko, Aleksander S Popel
A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor-Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy. Cancers 13 (15) (2021)
Adam C Mirando, Raquel Lima E Silva, Zenny Chu, Peter A Campochiaro, Niranjan B Pandey, Aleksander S Popel
Suppression of Ocular Vascular Inflammation through Peptide-Mediated Activation of Angiopoietin-Tie2 Signaling. International journal of molecular sciences 21 (14) (2020)
Aleksander S Popel
Immunoactivating the tumor microenvironment enhances immunotherapy as predicted by integrative computational model. Proceedings of the National Academy of Sciences of the United States of America 117 (9) (2020)
Adam C Mirando, Akash Patil, Christine I Rafie, Brian J Christmas, Niranjan B Pandey, Vered Stearns, Elizabeth D Thompson, Evanthia T Roussos Torres, Aleksander S Popel
Regulation of the tumor immune microenvironment and vascular normalization in TNBC murine models by a novel peptide. Oncoimmunology 9 (1) (2020)
Chen Zhao, Yu Zhang, Aleksander S Popel
Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases. International journal of molecular sciences 20 (2) (2019)
Kerri-Ann Norton, Chang Gong, Samira Jamalian, Aleksander S Popel
Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment. Processes (Basel, Switzerland) 7 (1) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Aleksander S Popel