The Effects of TNF-α Inhibition on the Metabolism of Cartilage: Relationship between KS, HA, HAPLN1 and ADAMTS4, ADAMTS5, TOS and TGF-β1 Plasma Concentrations in Patients with Juvenile Idiopathic Arthritis.
Kornelia Kuźnik-TrochaKatarzyna Winsz-SzczotkaIwona Lachór-MotykaKlaudia DąbkowskaMagdalena WojdasKrystyna OlczykKatarzyna Komosinska-VassevPublished in: Journal of clinical medicine (2022)
The anti-TNF-α therapy used in patients with JIA has a beneficial effect on ECM cartilage metabolism, but it does not completely regenerate it. The changes in the plasma HA level during the anti-cytokine therapy suggest its potential diagnostic utility in monitoring of disease activity and may be used to assess the efficacy of ETA treatment.