Clinical, histopathological and immunohistochemical evaluation of daylight photodynamic therapy in the treatment of field cancerization: a study of 30 cases.

Beatrice Martinez Zugaib AbdallaBruna Simas PedreiroAndrezza Garcia MoralesDebora Krutman ZveibilFrancisco Macedo Paschoal

Published in: The Journal of dermatological treatment (2020)

The study shows that PDT has cellular and molecular effects that support its indication in the control of carcinogenesis, as it decreases atypia and controls the expression of Ki67, reducing the proliferation of atypical cells. However, its indication following this study is still mainly aimed at clinical improvement of the skin, at this moment, probably due to the sample size.

Keyphrases

photodynamic therapy
induced apoptosis
poor prognosis
signaling pathway
radiation therapy
neoadjuvant chemotherapy
cell death
cell cycle arrest
cell proliferation
soft tissue
wound healing
smoking cessation
locally advanced
pi k akt