Splicing machinery is impaired in rheumatoid arthritis, associated with disease activity and modulated by anti-TNF therapy.
Alejandro Ibáñez-CostaCarlos Perez-SanchezAlejandra María Patiño-TrivesMaria Luque-TevarPilar FontIvan Arias de la RosaCristobal Roman-RodriguezMª Carmen Abalos-AguileraCarmen CondeAntonio GonzálezSergio Pedraza-ArevaloMercedes Del Rio-MorenoRicardo Blazquez-EncinasPedro SeguiJerusalem CalvoRafaela Ortega CastroAlejandro Escudero-ContrerasNuria BarbarrojaMª Angeles AguirreJusto P. CastañoRaul M LuqueEduardo Collantes-EstevezRosario Lopez-PedreraPublished in: Annals of the rheumatic diseases (2021)
Overall, we have characterised for the first time a signature comprising eight dysregulated SME in RA leucocytes from both peripheral blood and synovial fluid, linked to disease pathophysiology, modulated by ACPAs and reversed by anti-TNF therapy.