Shifting phenotype and differentiation of CD11b + Gr.1 + immature heterogeneous myeloid derived adjuster cells support inflammation and induce regulators of IL17A in imiquimod induced psoriasis.
Debanjan SarkarAnik PramanikDona DasSankar BhattacharyyaPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)
Our results indicate that altered MDAC properties in psoriatic condition sustains pathological inflammation and RORγt and NFAT1 as promising intervention target for psoriasis management.
Keyphrases
- oxidative stress
- induced apoptosis
- diabetic rats
- randomized controlled trial
- cell cycle arrest
- rheumatoid arthritis
- high glucose
- bone marrow
- acute myeloid leukemia
- transcription factor
- cell death
- disease activity
- endoplasmic reticulum stress
- immune response
- endothelial cells
- inflammatory response
- cell proliferation