Hypoxia-induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase-1 in multiple myeloma.

Ko AbeSho IkedaMiho NaraAkihiro KitadateHiroyuki TagawaNaoto Takahashi

Published in: Cancer medicine (2023)

These results suggest that the hypoxia-ROS-HMOX1 axis and hypoxia-induced MafB may be important mechanisms of proteasome inhibitor resistance in hypoxic microenvironments.

Keyphrases

oxidative stress
multiple myeloma
dna damage
cell death
poor prognosis
endothelial cells
reactive oxygen species
stem cells
ischemia reperfusion injury
diabetic rats
long non coding rna
cell therapy