Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms.

Jeremy Yuen Chun Teoh Xiao Yu Tian Christine Yim-Ping WongChi-Wai LauChak-Kwong ChengVictor Wai-Lun TangRonald Cheong-Kin Chan Yu Huang Chi-Fai Ng

Published in: The Prostate (2021)

ADT causes endothelial dysfunction in male rats. GnRH receptor agonist compared to GnRH receptor antagonist, showed more impairment of endothelial function in the aorta and intrarenal arteries. Such change might be associated with upregulation and activation of AngII-AT1R-NOX2 induced oxidative stress in the vasculature. These results help to explain the different cardiovascular risks and outcomes related to different modalities of ADT treatment.

Keyphrases

poor prognosis
cell proliferation
hydrogen peroxide
aortic valve
pulmonary artery
signaling pathway
reactive oxygen species
metabolic syndrome
coronary artery
replacement therapy
bone marrow
drug induced