Downregulated VISTA enhances Th17 differentiation and aggravates inflammation in patients with acute-on-chronic liver failure.

Yao ZhangXueyun ZhangJiajia HanYifei GuoFeifei YangFahong LiHaoxiang ZhuZhongliang ShenYuxian HuangRicheng MaoJi-Ming Zhang

Published in: Hepatology international (2023)

The decreased expression of VISTA may facilitate development of Th17 cells and promote the progression of inflammation in ACLF patients. These findings are helpful for elucidating the pathogenesis of ACLF and for the identification of new drug targets.

Keyphrases

liver failure
oxidative stress
end stage renal disease
induced apoptosis
newly diagnosed
ejection fraction
hepatitis b virus
chronic kidney disease
poor prognosis
peritoneal dialysis
emergency department
cell cycle arrest
patient reported outcomes
drug induced
cell proliferation
electronic health record