Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve in severe acute respiratory distress syndrome.
Zhanqi ZhaoMei-Ying ChangMei-Yun ChangChien-Hung GowJia-Hao ZhangYeong-Long HsuInez FrerichsHou-Tai ChangKnut MöllerPublished in: Annals of intensive care (2019)
In severe ARDS patients, it was feasible and safe to guide PEEP titration with EIT at the bedside. As compared with pressure-volume curve, the EIT-guided PEEP titration may be associated with improved oxygenation, compliance, driving pressure, and weaning success rate. The findings encourage further randomized control study with a larger sample size and potentially less bias in the baseline data. Trial Registration NCT03112512.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- end stage renal disease
- phase iii
- newly diagnosed
- ejection fraction
- clinical trial
- early onset
- open label
- intensive care unit
- phase ii
- double blind
- study protocol
- randomized controlled trial
- prognostic factors
- peritoneal dialysis
- magnetic resonance
- electronic health record