The preventive and therapeutic role of Lactobacillus spp. in in vitro model of inflammation via affecting autophagy signaling pathway.

Fatemeh Haririzadeh JourianiMahnaz TorfehMahdi TorkamanehAmin SepehrMahdi RohaniShadi Aghamohammad

Published in: Immunity, inflammation and disease (2024)

Our native probiotic Lactobacillus spp. showed beneficial effects on HT-29 cells by increasing autophagy gene expression and decreasing the proinflammatory cytokines production in all treatments. Therefore, this novel probiotic cocktail Lactobacillus spp. can prevent and treat inflammation-related diseases.

Keyphrases

induced apoptosis
oxidative stress
signaling pathway
lactic acid
endoplasmic reticulum stress
gene expression
cell death
cell cycle arrest
pi k akt
dna methylation
epithelial mesenchymal transition