Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation.
Seon Gyeong BakHyung-Jin LimYeong-Seon WonSoyoung LeeSun Hee CheongSeong Jin LeeEun Young BaeSeung Woong LeeSeung-Jae LeeMun-Chual RhoPublished in: BioMed research international (2022)
Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF- α )/interferon gamma (IFN- γ ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro . Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum , scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.
Keyphrases
- atopic dermatitis
- wound healing
- soft tissue
- oxidative stress
- rheumatoid arthritis
- endothelial cells
- induced apoptosis
- dendritic cells
- high glucose
- immune response
- drug induced
- diabetic rats
- anti inflammatory
- big data
- cell proliferation
- endoplasmic reticulum stress
- induced pluripotent stem cells
- deep learning
- replacement therapy
- artificial intelligence
- pluripotent stem cells