Evaluating the safety and potential activity of URO-902 (hMaxi-K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants with idiopathic (non-neurogenic) overactive bladder syndrome and detrusor overactivity from two double-blind, imbalanced, placebo-controlled randomized phase 1 trials.
Eric RovnerToby C ChaiSharon JacobsGeorge ChristKarl-Erik AnderssonMitchell EfrosVictor NittiKelvin DaviesAndrew R McCulloughArnold MelmanPublished in: Neurourology and urodynamics (2020)
Promising safety and efficacy results in these preliminary phase 1 studies suggest gene transfer may be a promising therapy for OAB/DO, warranting further investigation.