Biological Activity Of miRNA-27a Using Peptide-based Drug Delivery Systems.
Anna-Laurence Schachner-NedhererOliver WerzerKarin KornmuellerRuth PrasslAndreas ZimmerPublished in: International journal of nanomedicine (2019)
The present DDS assembled from amphipathic N-TER peptides and miRNAs is capable of inducing the anti-adipogenic effect of miRNA-27a by reducing lipid droplet accumulation in mature adipocytes. With respect to miRNA mimic replacement therapies, this approach might provide new therapeutic strategies to prevent or treat obesity and obesity-related disorders.