Biological Activity Of miRNA-27a Using Peptide-based Drug Delivery Systems.

Anna-Laurence Schachner-NedhererOliver Werzer Karin Kornmueller Ruth Prassl Andreas Zimmer

Published in: International journal of nanomedicine (2019)

The present DDS assembled from amphipathic N-TER peptides and miRNAs is capable of inducing the anti-adipogenic effect of miRNA-27a by reducing lipid droplet accumulation in mature adipocytes. With respect to miRNA mimic replacement therapies, this approach might provide new therapeutic strategies to prevent or treat obesity and obesity-related disorders.

Keyphrases

high fat diet induced
insulin resistance
metabolic syndrome
weight loss
type diabetes
weight gain
adipose tissue
body mass index
fatty acid
skeletal muscle
physical activity