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Biological Activity Of miRNA-27a Using Peptide-based Drug Delivery Systems.

Anna-Laurence Schachner-NedhererOliver WerzerKarin KornmuellerRuth PrasslAndreas Zimmer
Published in: International journal of nanomedicine (2019)
The present DDS assembled from amphipathic N-TER peptides and miRNAs is capable of inducing the anti-adipogenic effect of miRNA-27a by reducing lipid droplet accumulation in mature adipocytes. With respect to miRNA mimic replacement therapies, this approach might provide new therapeutic strategies to prevent or treat obesity and obesity-related disorders.
Keyphrases
  • high fat diet induced
  • insulin resistance
  • metabolic syndrome
  • weight loss
  • type diabetes
  • weight gain
  • adipose tissue
  • body mass index
  • fatty acid
  • skeletal muscle
  • physical activity