Serial assessment of biomarkers and the risk of stroke or systemic embolism and bleeding in patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial.

Kazuma Oyama Robert P GiuglianoDavid D BergChristian T RuffPetr Jarolím Minao TangSabina A MurphyHans J LanzMichael A GrossoElliott Marshall Antman Eugene Braunwald David A Morrow

Published in: European heart journal (2021)

Serial assessment of hsTnT, NT-proBNP, and GDF-15 revealed that a substantial proportion of patients with AF had dynamic values. Greater increases in these biomarkers measured over 1 year are associated with important clinical outcomes in anticoagulated patients with AF.

Keyphrases

atrial fibrillation
clinical trial
study protocol
single cell
phase iii
randomized controlled trial
brain injury
drug induced