IL-3 up-regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation.

Stephane EsnaultM W JohanssonE A KellyL KoendermanD F MosherN N Jarjour

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

We observed for the first time upregulation of CD32B/C on eosinophils, and identified IL-3 as a potent inducer of CD32- and αMß2-mediated eosinophil degranulation.

Keyphrases

endothelial cells
nk cells
cell proliferation
signaling pathway
poor prognosis
cell adhesion