Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.

Victor MontalEduard VilaplanaJordi Pegueroles Alexandre Bejanin Daniel AlcoleaMaría Carmona-IraguiJordi ClarimónJohannes LevinCarlos CruchagaNeill R Graff-RadfordJames M NobleJae-Hong LeeRicardo AllegriCeleste M KarchChristoph LaskePeter R SchofieldStephen SallowayBeau AncesTammie BenzingerEric McDaleRandall BatemanRafael Blesa Raquel Sanchez-Valle Alberto Lleó Juan Forteanull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2020)

These findings confirm a biphasic trajectory for brain structural changes and have direct implications when interpreting magnetic resonance imaging measures in preventive AD clinical trials.

Keyphrases

magnetic resonance imaging
white matter
clinical trial
resting state
cognitive decline
computed tomography
multiple sclerosis
contrast enhanced
functional connectivity
phase ii
cerebral ischemia
randomized controlled trial
open label
double blind
blood brain barrier