Serum Response Factor Is Essential for Prenatal Gastrointestinal Smooth Muscle Development and Maintenance of Differentiated Phenotype.
Chanjae ParkMoon Young LeePaul J ParkSe Eun HaRobyn M BerentRobert FuchsJoseph M MianoLaren S BeckerKenton M SandersSeungil RoPublished in: Journal of neurogastroenterology and motility (2015)
SRF expression in SMCs is essential for prenatal development of the GI tract and heart. Following partial obstruction, SMCs down-regulate SRF to transition into proliferative PDGFRα(low) cells that may represent a phenotype responsible for their plasticity. These findings demonstrate that SRF also plays a critical role in the remodeling process following GI injury.