Exosomal miRNA-21-5p and miRNA-21-3p as key biomarkers of myocardial infarction.

Reza SahebiFatemeh GandomiMitra ShojaeiEffat Farrokhi

Published in: Health science reports (2024)

This study revealed that the mean expression levels of exo-miRNA-21-5p/3p were significantly increased in CAD patients and animal models of induced MI. Also, these results are associated with the atherogenic lipid profile of CAD patients, which may play an important role in the progression of the disease. Therefore, they can be considered as novel biomarkers.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
coronary artery disease
heart failure
poor prognosis
left ventricular
endothelial cells
diabetic rats