Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca.
Bin-Bin GuFu-Rong JiaoWei WuWei-Hua JiaoLei LiFan SunShu-Ping WangFan YangHou-Wen LinPublished in: Journal of natural products (2018)
New pyrrolidine alkaloids, preussins C-I (1-7) and (11 R)/(11 S)-preussins J and K (8 and 9), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structures and configurations of these preussins were elucidated by detailed spectroscopic analysis, modified Mosher's method, and comparisons with literature data. These compounds showed strong to moderate inhibitory activity toward IL-6 production in lipopolysaccharide-induced THP-1 cells with IC50 values ranging from 0.11 to 22 μM, but were inactive against normal tumor cell lines and fungi.
Keyphrases
- lipopolysaccharide induced
- inflammatory response
- induced apoptosis
- poor prognosis
- systematic review
- cell cycle arrest
- molecular docking
- high resolution
- cell wall
- high intensity
- electronic health record
- endoplasmic reticulum stress
- oxidative stress
- binding protein
- data analysis
- machine learning
- mass spectrometry
- signaling pathway
- artificial intelligence
- deep learning