Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development.

Meghan MaguireMichele Campaigne LarsenChad M VezinaLoredana QuadroYoun-Kyung KimSherry A TanumihardjoColin R Jefcoate

Published in: PloS one (2020)

Cyp1b1-/- suppresses genes supported by Srebp. GVAD effects distinguish Srebp1 and Srebp2 mediation. Srebp regulation overlaps appreciably in cholesterol and retinoid homeostasis. Bco1/Cyp1b1 partnership in the STM may contribute to this later liver regulation.

Keyphrases

pregnant women
low density lipoprotein
signaling pathway
genome wide
social support
dna methylation
transcription factor