Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans.
Nadia O BamfoChelsea Hosey-CojocariLeslie Z BenetConnie M RemsbergPublished in: Pharmaceutical research (2021)
Drugs with high urinary excretion in animals are likely to have high urinary excretion in humans. Animal models tend to underpredict the urinary excretion of unchanged drug in humans.