Leslie Z Benet

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Topics

St Segment Elevation Myocardial Infarction

Clinical Decision Support

Top Venues

The AAPS journal

Drug metabolism and disposition: the biological fate of chemicals

Pharmaceutical research

Chemical research in toxicology

This page only lists publications with an associated author ORCID identifier.

Publications

Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Hirokazu Wakuda, Yue Xiang, Jasleen K Sodhi, Naoto Uemura, Leslie Z Benet
An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1) (2024)
Hirokazu Wakuda, Yue Xiang, Jasleen K Sodhi, Naoto Uemura, Leslie Z Benet
An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1) (2024)
Hirokazu Wakuda, Yue Xiang, Jasleen K Sodhi, Naoto Uemura, Leslie Z Benet
An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary Pharmacokinetic Theory Must Consider Published Experimental Data . Drug metabolism and disposition: the biological fate of chemicals (2024)
Hirokazu Wakuda, Yue Xiang, Jasleen K Sodhi, Naoto Uemura, Leslie Z Benet
An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 26 (1) (2024)
Leslie Z Benet, Jasleen K Sodhi
Commentary: Pharmacokinetic Theory Must Consider Published Experimental Data. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Leslie Z Benet, Jasleen K Sodhi
The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry. The AAPS journal 25 (3) (2023)
Wei Liu, Zhiheng Yu, Ziyu Wang, Emmanuelle L Waubant, Suodi Zhai, Leslie Z Benet
Using an animal model to predict the effective human dose for oral multiple sclerosis drugs. Clinical and translational science (2022)
Giovanni Bocci, Tudor I Oprea, Leslie Z Benet
State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. The AAPS journal 24 (2) (2022)
Nadia O Bamfo, Chelsea Hosey-Cojocari, Leslie Z Benet, Connie M Remsberg
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharmaceutical research 38 (7) (2021)
Jasleen K Sodhi, Leslie Z Benet
Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. Journal of medicinal chemistry 64 (7) (2021)
Leslie Z Benet, Jasleen K Sodhi, George Makrygiorgos, Ali Mesbah
There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions. The AAPS journal 23 (3) (2021)
Leslie Z Benet
Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing. Journal of clinical pharmacology 61 (6) (2021)
Shuaibing Liu, Jasleen K Sodhi, Leslie Z Benet
Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. Pharmaceutical research 38 (10) (2021)
Jasleen K Sodhi, Caroline H Huang, Leslie Z Benet
Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clinical pharmacokinetics 60 (2) (2021)
Wen Kou, Jasleen K Sodhi, Xin'an Wu, Leslie Z Benet
Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption. Pharmaceutical research 38 (5) (2021)
Jasleen K Sodhi, Leslie Z Benet
The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. The AAPS journal 22 (5) (2020)
Jasleen K Sodhi, Hong-Jaan Wang, Leslie Z Benet
Are There Any Experimental Perfusion Data that Preferentially Support the Dispersion and Parallel-Tube Models over the Well-Stirred Model of Organ Elimination? Drug metabolism and disposition: the biological fate of chemicals 48 (7) (2020)
Jasleen K Sodhi, Shuaibing Liu, Leslie Z Benet
Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. Pharmaceutical research 37 (10) (2020)
Leslie Z Benet, Jasleen K Sodhi
Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. The AAPS journal 22 (5) (2020)
Li Di, Per Artursson, Alex Avdeef, Leslie Z Benet, J Brian Houston, Manfred Kansy, Edward H Kerns, Hans Lennernäs, Dennis A Smith, Kiyohiko Sugano
The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem 15 (20) (2020)
Wei Liu, Tingting Yan, Ken Chen, Li Yang, Leslie Z Benet, Suo-di Zhai
Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System. Pharmacotherapy 40 (4) (2020)
Christine M Bowman, Hideaki Okochi, Leslie Z Benet
The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug metabolism and disposition: the biological fate of chemicals 47 (4) (2019)
Christine M Bowman, Leslie Z Benet
In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly. Drug metabolism and disposition: the biological fate of chemicals 47 (12) (2019)
Yuu Moriya, Akifumi Kogame, Yoshihiko Tagawa, Akio Morohashi, Takahiro Kondo, Satoru Asahi, Leslie Z Benet
The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats. Drug metabolism and disposition: the biological fate of chemicals 47 (9) (2019)
Dalga D Surofchy, Lynda A Frassetto, Leslie Z Benet
Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharmaceutical research 36 (11) (2019)
Leslie Z Benet, Christine M Bowman, Megan L Koleske, Capria L Rinaldi, Jasleen K Sodhi
Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. Journal of pharmacokinetics and pharmacodynamics 46 (2) (2019)
Christine M Bowman, Leslie Z Benet
Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical research 36 (8) (2019)
Leslie Z Benet, Christine M Bowman, Jasleen K Sodhi
How Transporters Have Changed Basic Pharmacokinetic Understanding. The AAPS journal 21 (6) (2019)
Leslie Z Benet, Priya Jayachandran, Kevin J Carroll, Elise Burmeister Getz
Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clinical pharmacology and therapeutics 105 (2) (2019)
Leslie Z Benet, Christine M Bowman, Shufang Liu, Jasleen K Sodhi
The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharmaceutical research 35 (12) (2018)
Rosa Chan, Leslie Z Benet
Evaluation of DILI Predictive Hypotheses in Early Drug Development. Chemical research in toxicology 30 (4) (2017)