The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.
Beril TutuncuogluMerve CakirJyoti BatraMehdi BouhaddouManon EckhardtDavid E GordonNevan J KroganPublished in: Cancer discovery (2020)
The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.
Keyphrases
- sars cov
- endothelial cells
- respiratory syndrome coronavirus
- papillary thyroid
- induced pluripotent stem cells
- squamous cell
- healthcare
- single cell
- pluripotent stem cells
- emergency department
- transcription factor
- risk factors
- lymph node metastasis
- squamous cell carcinoma
- cancer therapy
- young adults
- childhood cancer
- climate change