Our findings reveal a complex proteomic landscape in skeletal muscle exposed to sepsis and disuse, consistent with an exacerbation of muscle protein degradation under these combined stressors. The identified proteins and their roles in cellular stress responses and muscle pathology provide potential targets for intervention to mitigate muscle dysfunction in septic conditions, highlighting the importance of addressing both sepsis and disuse concurrently in clinical and experimental settings.
Keyphrases
- skeletal muscle
- acute kidney injury
- septic shock
- insulin resistance
- intensive care unit
- single cell
- randomized controlled trial
- chronic obstructive pulmonary disease
- oxidative stress
- label free
- genome wide
- type diabetes
- protein protein
- adipose tissue
- small molecule
- human health
- risk assessment
- mechanical ventilation