Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition.
Elisha HughesSusanne WagnerDmitry PrussRyan BernhiselBraden ProbstVictor AbkevichTimothy SimmonsBrooke HullingerThaddeus JudkinsEric RosenthalBenjamin RoaSusan M DomchekCharis EngJudy E GarberMonique GaryJennifer R KlempSemanti MukherjeeKenneth OffitOlufunmilayo I OlopadeJoseph VijaiJeffrey N WeitzelPat WhitworthLamis YehiaOra GordonHolly PedersonAllison W KurianThomas P SlavinAlexander GutinJerry S LanchburyPublished in: JCO precision oncology (2022)
The MA-PRS uses genetic ancestral composition to expand the utility of polygenic risk prediction to non-European women. Inclusion of genetic ancestry in polygenic risk prediction presents an opportunity for more personalized treatment decisions for women of varying and mixed ancestries.