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Charis Eng (C Eng)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 56

Top Venues

The journal of physical chemistry. B

Translational psychiatry

JCO precision oncology

NPJ genomic medicine

Case Western Reserve University School of Medicine

University of Chicago (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Case Western Reserve University School of Medicine Sep 1o 2005

United States

Professor and Vice Chair :: Genetics and Genome Sciences

Education History

University of Chicago Oct 1o 1982

United States

PHD :: Developmental Biology, Biological Sciences Division of Pritzker School of Medicine

Publications

Takae Brewer, Lamis Yehia, Peter Bazeley, Charis Eng
Integrating somatic CNV and gene expression in breast cancers from women with PTEN hamartoma tumor syndrome. NPJ genomic medicine 8 (1) (2023)
Shyam K Poudel, Roshan Padmanabhan, Heloni Dave, Kathryn Guinta, Tyler Stevens, Madhusudhan R Sanaka, Prabhleen Chahal, Davendra P S Sohal, Alok A Khorana, Charis Eng
Microbiomic profiles of bile in patients with benign and malignant pancreaticobiliary disease. PloS one 18 (4) (2023)
Kelly Metcalfe, Tomasz Huzarski, Jacek Gronwald, Joanne Kotsopoulos, Raymond Kim, Pal Moller, Tuya Pal, Amber Aeilts, Andrea Eisen, Beth Y Karlan, Louise Bordeleau, Nadine Tung, Olufunmilayo I Olopade, Dana Zakalik, Christian F Singer, William Foulkes, Fergus Couch, Susan L Neuhausen, Charis Eng, Ping Sun, Jan Lubinski, Steven A Narod, null null
Risk-reducing mastectomy and breast cancer mortality in women with a BRCA1 or BRCA2 pathogenic variant: an international analysis. British journal of cancer (2023)
Shelly A Cummings, Andrew Alfonso, Elisha Hughes, Matt Kucera, Brent Mabey, Nanda Singh, Charis Eng
Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing. JCO precision oncology 7 (2023)
Shelly A Cummings, Andrew Alfonso, Elisha Hughes, Matt Kucera, Brent Mabey, Nanda Singh, Charis Eng
Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing. JCO precision oncology 7 (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B (2023)
Masahiro Hitomi, Juan Venegas, Shin Chung Kang, Charis Eng
Differential cell cycle checkpoint evasion by PTEN germline mutations associated with dichotomous phenotypes of cancer versus autism spectrum disorder. Oncogene (2023)
Shin Chung Kang, Nicholas B Sarn, Juan Venegas, Zhibing Tan, Masahiro Hitomi, Charis Eng
Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids. Molecular psychiatry (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Shelly A Cummings, Andrew Alfonso, Elisha Hughes, Matt Kucera, Brent Mabey, Nanda Singh, Charis Eng
Cancer Risk Associated With PTEN Pathogenic Variants Identified Using Multigene Hereditary Cancer Panel Testing. JCO precision oncology 7 (2023)
Emma Guyonnet, Shana J Kim, Yue Yin Xia, Vasily Giannakeas, Jan A Lubiński, Susan Randall Armel, Andrea Eisen, Louise Bordeleau, Charis Eng, Olufunmilayo I Olopade, Nadine M Tung, William D Foulkes, Fergus J Couch, Amber M Aeilts, Steven A Narod, Joanne Kotsopoulos
Physical Activity During Adolescence and Early-adulthood and Ovarian Cancer Among Women with a BRCA1 or BRCA2 Mutation. Cancer research communications 3 (11) (2023)
Courtney E Hershberger, Shreya Louis, Robyn M Busch, Deborah Vegh, Imad Najm, Peter Bazeley, Charis Eng, Lara Jehi, Daniel M Rotroff
Molecular subtypes of epilepsy associated with post-surgical seizure recurrence. Brain communications 5 (5) (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Iris Nira Smith, Jennifer E Dawson, Charis Eng
Comparative Protein Structural Network Analysis Reveals C-Terminal Tail Phosphorylation Structural Communication Fingerprint in PTEN -Associated Mutations in Autism and Cancer. The journal of physical chemistry. B 127 (3) (2023)
Erin E Mulkearns-Hubert, Emily E Rhoades, Salma Ben-Salem, Rashmi Bharti, Nicole Hajdari, Sarah Johnson, Alex Myers, Iris Nira Smith, Smarajit Bandyopadhyay, Charis Eng, Erinn Downs-Kelly, Justin D Lathia, Ofer Reizes
Targeting NANOG and FAK via Cx26-derived cell-penetrating peptides in triple-negative breast cancer. Molecular cancer therapeutics (2023)
Seth J Rotz, Naseer Sangwan, Matthew Nagy, Alice Tzeng, Margaret Jia, Maria Moncaliano, Navneet S Majhail, Charis Eng
Fecal microbiota of adolescent and young adult cancer survivors and metabolic syndrome: an exploratory study. Pediatric hematology and oncology 39 (7) (2022)
Iris N Smith, Jennifer E Dawson, James Krieger, Stetson Thacker, Ivet Bahar, Charis Eng
Structural and Dynamic Effects of PTEN C-Terminal Tail Phosphorylation. Journal of chemical information and modeling 62 (17) (2022)
Robyn M Busch, Lamis Yehia, Ingmar Bluemcke, Bo Hu, Richard Prayson, Bruce P Hermann, Imad M Najm, Charis Eng
Molecular and subregion mechanisms of episodic memory phenotypes in temporal lobe epilepsy. Brain communications 4 (6) (2022)
Elisha Hughes, Susanne Wagner, Dmitry Pruss, Ryan Bernhisel, Braden Probst, Victor Abkevich, Timothy Simmons, Brooke Hullinger, Thaddeus Judkins, Eric Rosenthal, Benjamin Roa, Susan M Domchek, Charis Eng, Judy E Garber, Monique Gary, Jennifer R Klemp, Semanti Mukherjee, Kenneth Offit, Olufunmilayo I Olopade, Joseph Vijai, Jeffrey N Weitzel, Pat Whitworth, Lamis Yehia, Ora Gordon, Holly Pederson, Allison W Kurian, Thomas P Slavin, Alexander Gutin, Jerry S Lanchbury
Development and Validation of a Breast Cancer Polygenic Risk Score on the Basis of Genetic Ancestry Composition. JCO precision oncology 6 (2022)
Lamis Yehia, Ying Ni, Tammy Sadler, Thomas W Frazier, Charis Eng
Distinct metabolic profiles associated with autism spectrum disorder versus cancer in individuals with germline PTEN mutations. NPJ genomic medicine 7 (1) (2022)
Lamis Yehia, Charis Eng
One Size Does Not Fit All: Breast Cancer in Young Women. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (11) (2022)
Jennifer E Dawson, Iris Nira Smith, William Martin, Krishnendu Khan, Feixiong Cheng, Charis Eng
Shape shifting: The multiple conformational substates of the PTEN N-terminal PIP 2 -binding domain. Protein science : a publication of the Protein Society 31 (5) (2022)
Joanne Kotsopoulos, Jan Lubinski, Jacek Gronwald, Janusz Menkiszak, Jeanna McCuaig, Kelly Metcalfe, William D Foulkes, Susan L Neuhausen, Sophie Sun, Beth Y Karlan, Andrea Eisen, Nadine Tung, Olufunmilayo I Olopade, Fergus J Couch, Tomasz Huzarski, Leigha Senter, Louise Bordeleau, Christian F Singer, Charis Eng, Robert Fruscio, Tuya Pal, Ping Sun, Steven A Narod
Bilateral Oophorectomy and the Risk of Breast Cancer in BRCA1 Mutation Carriers: A Reappraisal. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31 (7) (2022)
Gilman Plitt, Takae Brewer, Lamis Yehia, Judy Jin, Joyce Shin, Charis Eng
Development and Progression of Thyroid Disease in PTEN Hamartoma Tumor Syndrome: Refined Surveillance Recommendations. Thyroid : official journal of the American Thyroid Association 32 (9) (2022)
Robyn M Busch, Lamis Yehia, Bo Hu, Melissa Goldman, Bruce P Hermann, Imad M Najm, Steven A McCarroll, Charis Eng
Brain single cell transcriptomic profiles in episodic memory phenotypes associated with temporal lobe epilepsy. NPJ genomic medicine 7 (1) (2022)
Shana J Kim, Jan Lubinski, Tomasz Huzarski, Pål Møller, Susan Armel, Beth Y Karlan, Leigha Senter, Andrea Eisen, William D Foulkes, Christian F Singer, Nadine Tung, Louise Bordeleau, Susan L Neuhausen, Olufunmilayo I Olopade, Charis Eng, Jeffrey N Weitzel, Robert Fruscio, Steven A Narod, Joanne Kotsopoulos, null null
Weight Gain and the Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 30 (11) (2021)
Stetson Thacker, Charis Eng
Transcriptome-(phospho)proteome characterization of brain of a germline model of cytoplasmic-predominant Pten expression with autism-like phenotypes. NPJ genomic medicine 6 (1) (2021)
Lamis Yehia, Darren Liu, Shuai Fu, Pranav Iyer, Charis Eng
Non-canonical role of wild-type SEC23B in the cellular stress response pathway. Cell death & disease 12 (4) (2021)
Feixiong Cheng, Junfei Zhao, Yang Wang, Weiqiang Lu, Zehui Liu, Yadi Zhou, William R Martin, Ruisheng Wang, Jin Huang, Tong Hao, Hong Yue, Jing Ma, Yuan Hou, Jessica A Castrillon, Jiansong Fang, Justin D Lathia, Ruth A Keri, Felice C Lightstone, Elliott Marshall Antman, Raúl Rabadán, David E Hill, Charis Eng, Marc Vidal, Joseph Loscalzo
Comprehensive characterization of protein-protein interactions perturbed by disease mutations. Nature genetics 53 (3) (2021)
Thomas W Frazier, Ritika Jaini, Robyn M Busch, Matthew Wolf, Tammy Sadler, Patricia Klaas, Antonio Y Hardan, Julian A Martinez, Mustafa Sahin, Charis Eng, null null
Cross-level analysis of molecular and neurobehavioral function in a prospective series of patients with germline heterozygous PTEN mutations with and without autism. Molecular autism 12 (1) (2021)
Nick Sarn, Stetson Thacker, Hyunpil Lee, Charis Eng
Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity. Molecular autism 12 (1) (2021)
Alice Tzeng, Naseer Sangwan, Margaret Jia, Chin-Chih Liu, Karen S Keslar, Erinn Downs-Kelly, Robert L Fairchild, Zahraa Al-Hilli, Stephen R Grobmyer, Charis Eng
Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer. Genome medicine 13 (1) (2021)
Ritika Jaini, Matthew R Wolf, Qi Yu, Alexander T King, Thomas W Frazier, Charis Eng
Maternal genetics influences fetal neurodevelopment and postnatal autism spectrum disorder-like phenotype by modulating in-utero immunosuppression. Translational psychiatry 11 (1) (2021)
Sara Akhavanfard, Roshan Padmanabhan, Lamis Yehia, Feixiong Cheng, Charis Eng
Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors. Nature communications 11 (1) (2020)
Robyn M Busch, Lamis Yehia, Peter Bazeley, Marilyn Seyfi, Ingmar Bluemcke, Bruce P Hermann, Imad M Najm, Charis Eng
Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy. Epilepsia 61 (10) (2020)
Megan Sheehan, Brandie Heald, Courtney Yanda, Erinn Downs Kelly, Stephen R Grobmyer, Charis Eng, Matthew F Kalady, Holly Pederson
Investigating the Link between Lynch Syndrome and Breast Cancer. European journal of breast health 16 (2) (2020)
Yadi Zhou, Yuan Hou, Jiayu Shen, Reena Mehra, Asha Kallianpur, Daniel A Culver, Michaela U Gack, Samar Farha, Joe Zein, Suzy Comhair, Claudio Fiocchi, Thaddeus S Stappenbeck, Timothy Chan, Charis Eng, Jae U Jung, Lara E Jehi, Serpil Erzurum, Feixiong Cheng
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19. PLoS biology 18 (11) (2020)
Nicholas Sarn, Ritika Jaini, Stetson Thacker, Hyunpil Lee, Ranjan Dutta, Charis Eng
Cytoplasmic-predominant Pten increases microglial activation and synaptic pruning in a murine model with autism-like phenotype. Molecular psychiatry 26 (5) (2020)
Giuseppe Novelli, Antonio Novelli, Paola Borgiani, Dario Cocciadiferro, Michela Biancolella, Emanuele Agolini, Marco Pietrosanto, Rosario Casalone, Manuela Helmer-Citterich, Emiliano Giardina, Suresh K Jain, Wenyi Wei, Charis Eng, Pier Paolo Pandolfi
WWP1 germline variants are associated with normocephalic autism spectrum disorder. Cell death & disease 11 (7) (2020)
Stetson Thacker, Marilyn Sefyi, Charis Eng
Alternative splicing landscape of the neural transcriptome in a cytoplasmic-predominant Pten expression murine model of autism-like Behavior. Translational psychiatry 10 (1) (2020)
Feixiong Cheng, Weiqiang Lu, Chuang Liu, Jiansong Fang, Yuan Hou, Diane E Handy, Ruisheng Wang, Yuzheng Zhao, Yi Yang, Jin Huang, David E Hill, Marc Vidal, Charis Eng, Joseph Loscalzo
A genome-wide positioning systems network algorithm for in silico drug repurposing. Nature communications 10 (1) (2019)
Jessica L Mester, Rajarshi Ghosh, Tina Pesaran, Robert Huether, Rachid Karam, Kathleen S Hruska, Helio A Costa, Katherine Lachlan, Joanne Ngeow Yuen Yie, Jill Barnholtz-Sloan, Kaitlin Sesock, Felicia Hernandez, Liying Zhang, Laura Milko, Sharon E Plon, Madhuri Hegde, Charis Eng
Gene-specific criteria for PTEN variant curation: Recommendations from the ClinGen PTEN Expert Panel. Human mutation 39 (11) (2019)
Hyunpil Lee, Stetson Thacker, Nicholas Sarn, Ranjan Dutta, Charis Eng
Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder. Translational psychiatry 9 (1) (2019)
Edgar A Rivera-Muñoz, Laura V Milko, Steven M Harrison, Danielle R Azzariti, C Lisa Kurtz, Kristy Lee, Jessica L Mester, Meredith A Weaver, Erin Currey, William Craigen, Charis Eng, Birgit Funke, Madhuri Hegde, Ray E Hershberger, Rong Mao, Robert D Steiner, Lisa M Vincent, Christa L Martin, Sharon E Plon, Erin Ramos, Heidi L Rehm, Michael Watson, Jonathan S Berg
ClinGen Variant Curation Expert Panel experiences and standardized processes for disease and gene-level specification of the ACMG/AMP guidelines for sequence variant interpretation. Human mutation 39 (11) (2019)
Robyn M Busch, Siddharth Srivastava, Olivia Hogue, Thomas W Frazier, Patricia Klaas, Antonio Hardan, Julian A Martinez-Agosto, Mustafa Sahin, Charis Eng, null null
Neurobehavioral phenotype of autism spectrum disorder associated with germline heterozygous mutations in PTEN. Translational psychiatry 9 (1) (2019)
Iris Nira Smith, Stetson Thacker, Ritika Jaini, Charis Eng
Dynamics and structural stability effects of germline PTEN mutations associated with cancer versus autism phenotypes. Journal of biomolecular structure & dynamics 37 (7) (2018)
Madhav Sankunny, Charis Eng
KLLN-mediated DNA damage-induced apoptosis is associated with regulation of p53 phosphorylation and acetylation in breast cancer cells. Cell death discovery 4 (2018)
Hannah Wang, Pauline Funchain, Gurkan Bebek, Jessica Altemus, Huan Zhang, Farshad Niazi, Charissa Peterson, Walter T Lee, Brian B Burkey, Charis Eng
Microbiomic differences in tumor and paired-normal tissue in head and neck squamous cell carcinomas. Genome medicine 9 (1) (2017)
Hannah Jinlian Chen, Todd Romigh, Kaitlin Sesock, Charis Eng
Characterization of cryptic splicing in germline PTEN intronic variants in Cowden syndrome. Human mutation 38 (10) (2017)
Samantha Colby, Lamis Yehia, Farshad Niazi, JinLian Chen, Ying Ni, Jessica L Mester, Charis Eng
Exome sequencing reveals germline gain-of-function EGFR mutation in an adult with Lhermitte-Duclos disease. Cold Spring Harbor molecular case studies 2 (6) (2017)
Kiyomi Yamazaki, Charis Eng, Sergei A Kuznetsov, John Reinisch, Dennis-Duke Yamashita, John Walker, Craig Cheung, Pamela G Robey, Stephen L-K Yen
Missense mutation in the PTEN promoter of a patient with hemifacial hyperplasia. BoneKEy reports 4 (2015)
Emily A Nizialek, Jessica L Mester, Vineet K Dhiman, Dominic J Smiraglia, Charis Eng
KLLN epigenotype-phenotype associations in Cowden syndrome. European journal of human genetics : EJHG 23 (11) (2015)
A K Tilot, G Bebek, F Niazi, J B Altemus, T Romigh, T W Frazier, Charis Eng
Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder. Molecular psychiatry 21 (1) (2015)

Charis Eng.css-eqlu8i{font-size:small;padding-left:4px;} (C Eng)

Publication Activity (10 Years)

Top Topics

Top Venues

Charis Eng (C Eng)