IL-1 family cytokines and soluble receptors in systemic lupus erythematosus.
Paola ItalianiMaria Laura MancaFrancesca AngelottiDaniela MelilloFederico PratesiIlaria PuxedduDiana BoraschiPaola MiglioriniPublished in: Arthritis research & therapy (2018)
The data support the use of IL-18, sIL-1R2 and sIL-1R4 as biomarkers of disease activity and organ involvement, and suggest that failure in the inhibition of IL-1 activation may be a critical event in the active stages of SLE.