Protective effects of swimming exercises and metformin on cardiac and aortic damage caused by a high-fat diet in obese rats with type 2 diabetes, by regulating the Bcl2/Bax signaling pathway.
Ebru ÖzüdoğruEmrah AtayMehtap SavranHalil AşçiOzlem OzmenSenay TopsakalPublished in: Turkish journal of medical sciences (2023)
It was observed that the MET and EXE treatments in the DM-2 model reduced cellular damage mechanisms such as inflammation and apoptosis. The decrease in NES-1 levels was thought to be secondary to this antiinflammatory effect. In conclusion, the results demonstrated the effectiveness of EXE in reducing DM-2 and the NES-1 levels. Further studies are needed to evaluate the effect in different EXE models and treatment durations.
Keyphrases
- high fat diet
- oxidative stress
- adipose tissue
- signaling pathway
- insulin resistance
- left ventricular
- randomized controlled trial
- induced apoptosis
- metabolic syndrome
- type diabetes
- endoplasmic reticulum stress
- aortic valve
- epithelial mesenchymal transition
- cell death
- pi k akt
- cell cycle arrest
- tyrosine kinase
- pulmonary artery
- pulmonary hypertension
- skeletal muscle