Novel peptide-based oncolytic vaccine for enhancement of adaptive antitumor immune response via co-engagement of innate Fcγ and Fcα receptors.

Sara Feola Firas Hamdan Salvatore RussoJacopo ChiaroManlio FuscielloMichaela FeodoroffGabriella AntignaniFederica D'AlessioRiikka MölsäVirpi StigzeliusPaolo BottegaSari PesonenJeanette H W LeusenMikaela GrönholmVincenzo Cerullo

Published in: Journal for immunotherapy of cancer (2024)

Our data suggest that exploiting innate immunity activates T-cell antitumor responses, enhancing the efficiency of a vaccine platform based on oncolytic adenovirus coated with MHC-I-restricted tumor peptides.

Keyphrases

immune response
toll like receptor
electronic health record
social media
big data
high throughput
gene therapy
deep learning