Identification of histone acetylation markers in human fetal brains and increased H4K5ac expression in neural tube defects.

Dan LiChunlei WanBaoling BaiHaiyan CaoChangyun LiuQin Zhang

Published in: Molecular genetics & genomic medicine (2019)

Our result present a comprehensive map of histone H4 modifications in the human fetal brain. Furthermore, we provide experimental evidence supporting a relationship between histone H4K5ac and NTDs. This offers a new insight into the pathological role of histone modifications in human NTDs.

Keyphrases

endothelial cells
dna methylation
induced pluripotent stem cells
pluripotent stem cells
long non coding rna
blood brain barrier
functional connectivity
brain injury
subarachnoid hemorrhage
resting state