Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation.
Selami DemirciJuan J Haro-MoraAlexis LeonardClaire DrysdaleDaniela MalideKeyvan KeyvanfarKhaled EssawiRaul VizcardoNaritaka TamaokiNicholas P RestifoJohn F TisdaleNaoya UchidaPublished in: Stem cell research & therapy (2020)
In summary, definitive HSPCs can be derived from ESCs through a dynamic cellular process from an organoid-like structure, where erythroid progeny are capable of producing adult hemoglobin and lymphoid progeny shows a diverse TCR repertoire.
Keyphrases
- embryonic stem cells
- endothelial cells
- high glucose
- locally advanced
- diabetic rats
- regulatory t cells
- induced pluripotent stem cells
- pluripotent stem cells
- drug induced
- squamous cell carcinoma
- oxidative stress
- radiation therapy
- rectal cancer
- red blood cell
- childhood cancer
- high throughput sequencing
- dendritic cells