Development of a mouse model of ascending infection and preterm birth.

Nicholas R Spencer Enkhtuya RadnaaTuvshintugs BaljinnyamTalar KechichianOurlad Alzeus Gaddi TantengcoElizabeth BonneyAnanth Kumar KammalaSamantha Sheller-Miller Ramkumar Menon

Published in: PloS one (2021)

We report the development of mouse model of ascending infection and the associated inflammation of preterm birth. Clinically, these models can help to understand mechanisms of infection associated preterm birth, determine targets for intervention, or identify potential biomarkers that can predict a high-risk pregnancy status early in pregnancy.

Keyphrases

preterm birth
mouse model
low birth weight
gestational age
randomized controlled trial
oxidative stress
pulmonary artery
coronary artery