An innovative lab-scale production for a novel therapeutic DNA vaccine candidate against rheumatoid arthritis.

Juan LongXiao ZhaoFei LiangYang ZengNan LiuYuying SunYongzhi Xi

Published in: Journal of biological engineering (2024)

The proposed innovative downstream process for the pcDNA-CCOL2A1 vaccine can not only provide a large-scale high-quality supercoiled plasmid DNA for preclinical research but also facilitate further pilot-scale and even industrial-scale production of pcDNA-CCOL2A1 vaccine.

Keyphrases

rheumatoid arthritis
circulating tumor
cell free
single molecule
escherichia coli
wastewater treatment
crispr cas
randomized controlled trial
stem cells
clinical trial
bone marrow