Synthesis of (Het)aryl 2-(2-hydroxyaryl)cyclopropyl Ketones.
Alexander A FadeevAlexey O ChagarovskiyAnton S MakarovIrina I LevinaOlga A IvanovaMaxim G UchuskinIgor V TrushkovPublished in: Molecules (Basel, Switzerland) (2020)
A simple general method for the synthesis of 1-acyl-2-(ortho-hydroxyaryl)cyclopropanes, which belong to the donor-acceptor cyclopropane family, has been developed. This method, based on the Corey-Chaykovsky cyclopropanation of 2-hydroxychalcones, allows for the preparation of a large diversity of hydroxy-substituted cyclopropanes, which can serve as promising building blocks for the synthesis of various bioactive compounds.