Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Shunsuke KatsukiPrabhash K JhaAdrien Lupieri Toshiaki Nakano Livia S A PassosMaximillian A RogersDakota Becker-GreeneThanh-Dat LeJulius L Decano Lang Ho LeeGabriel C GuimaraesIlyes AbdelhamidArda HaluAlessandro MuscoloniCarlo V CannistraciHideyuki HigashiHengmin ZhangAmélie VrommanPeter Libby C Keith OzakiAmitabh SharmaSasha A Singh Elena Aikawa Masanori Aikawa

Published in: Circulation research (2022)

Circulating PCSK9 induces macrophage activation and vein graft lesion development via LDLR-independent mechanisms. PCSK9 may be a potential target for pharmacologic treatment for this unmet medical need.

Keyphrases

low density lipoprotein
adipose tissue
healthcare
combination therapy
risk assessment
climate change