SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback.

Camila H CoelhoNathaniel BloomSydney I RamirezUrvi M ParikhAmy HeapsScott F SiegAlexander L GreningerJustin RitzCarlee MoserJoseph J EronJudith S CurrierPaul KlekotkaDavid A WohlEric S DaarJonathan LiMichael D HughesKara W ChewDavey M SmithShane Crottynull null

Published in: bioRxiv : the preprint server for biology (2023)

Evaluating the therapeutic use of monoclonal antibodies during SARS-CoV-2 infection requires a comprehensive understanding of their impact on B cell responses at the cellular level and how these responses are shaped after vaccination. We report for the first time the effect of bamlanivimab on SARS-CoV-2 specific human memory B cells of COVID-19 infected humans receiving, or not, mRNA immunization.

Keyphrases

sars cov
monoclonal antibody
respiratory syndrome coronavirus
endothelial cells
coronavirus disease
working memory
induced pluripotent stem cells
pluripotent stem cells
smoking cessation