A facile sonochemical protocol for synthesis of 3-amino- and 4-amino-1,2,4-triazole derived Schiff bases as potential antibacterial agents.
Aeysha SultanMian Habib Ur RehmanNoreen SajjadAli IrfanIrfan UllahMuhammad MustaqeemMuhammad SaleemSyeda Laila RubabMuhammad RafiqMuhammad KhalidKatarzyna Kotwica-MojzychMariusz MojzychPublished in: PloS one (2020)
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were characterized by means of IR, 1HNMR and Mass spectrometry. The synthesized compounds were also screened for their antibacterial potential against Gram-negative (Escherichia coli, Shigella sonnei, Pseudomonas aeruginosa and Salmonella typhi) and two Gram-positive (Staphylococcus aureus and Bacillus subtilis) strains.
Keyphrases
- gram negative
- escherichia coli
- multidrug resistant
- bacillus subtilis
- pseudomonas aeruginosa
- staphylococcus aureus
- mass spectrometry
- biofilm formation
- high resolution
- acinetobacter baumannii
- quantum dots
- randomized controlled trial
- cystic fibrosis
- highly efficient
- silver nanoparticles
- klebsiella pneumoniae
- liquid chromatography
- drug resistant
- reduced graphene oxide
- human health
- molecular docking
- metal organic framework
- risk assessment
- anti inflammatory
- wound healing
- amino acid
- gas chromatography
- oxide nanoparticles
- molecular dynamics simulations