Intracellular cGMP increase is not involved in thyroid cancer cell death.

Sara D' AlessandroElia ParadisoClara LazzarettiSamantha SperdutiCarmela PerriFrancesco AntonianiSara RighiManuela SimoniGiulia BriganteCasarini Livio

Published in: PloS one (2023)

This study demonstrates that increased cGMP levels are not linked to cell viability or death in K1 and Nthy-ori 3-1 cell lines, suggesting that PDE5i do not impact the growth of thyroid cancer cells. Since different results were previously published, further investigations are recommended to clarify the impact of PDE5i on thyroid cancer cells.

Keyphrases

cell death
nitric oxide
protein kinase
randomized controlled trial
reactive oxygen species
systematic review