PI3K/AKT and MAPK1 molecular changes preceding matrix metallopeptidases overexpression during tamoxifen-resistance development are correlated to poor prognosis in breast cancer patients.

Lama A HamadnehMohamad BahaderRama AbuarqoubMohammad AlWahshAla AlhusbanSuhair Hikmat

Published in: Breast cancer (Tokyo, Japan) (2021)

Early changes of MAPK1, AKT1 gene expression upon tamoxifen treatment could possibly be used as an early marker of resistance and future poor prognosis.

Keyphrases

poor prognosis
pi k akt
signaling pathway
cell proliferation
gene expression
long non coding rna
cell cycle arrest
breast cancer cells
estrogen receptor
positive breast cancer
dna methylation
current status
transcription factor
cell death
single molecule
replacement therapy