Chronic Stress Dampens Lactobacillus Johnsonii-Mediated Tumor Suppression to Enhance Colorectal Cancer Progression.

Qiuhua Cao Mingrui Zhao Yali Su Siliang Liu Yanting Lin Huijuan Da Chongxiu Yue Yiming Liu Dongquan Jing Qixiang Zhao Ning Liu Juan Du Zhanjie Zuo Yao Fu Anqi Chen Lutz Birnbaumer Yong Yang Beiying Dai Xinghua Gao

Published in: Cancer research (2024)

Chronic stress stimulates cancer stemness by reducing the intestinal abundance of L. johnsonii and its metabolite PCA to enhance β-catenin signaling, forming a basis for potential strategies to circumvent stress-induced cancer aggressiveness. See related commentary by McCollum and Shah, p. 645.

Keyphrases

stress induced
papillary thyroid
squamous cell
lymph node metastasis
epithelial mesenchymal transition
squamous cell carcinoma
drug induced
risk assessment
heat stress
lactic acid